Benserazide HCl14919-77-8盐酸苄丝肼

Benserazide HCl14919-77-8盐酸苄丝肼

盐酸苄丝肼
分子式：   C10H15N3O5.HCl 分子量：293.71
 
产品描述
Benserazide 是一种外周性的芳香族L-氨基酸脱羧酶（AAAD）或DOPA脱羧酶抑制剂。
靶点
          
IC50
          
生物活性
Benserazide is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor. It inhibits this decarboxylation, and since it itself cannot cross the blood-brain barrier, this allows dopamine to build up solely in the brain instead. Adverse effects caused by peripheral dopamine, such as nausea and arrhythmia, are minimized. However, benserazide cannot reduce the centrally-mediated side effects of levodopa, particularly dyskinesia.
溶解性
DMSO 59 mg/mL，水 59 mg/mL，乙醇 2 mg/mL
稳定性
2年 -20°C粉状，6月-80°C溶于DMSO