(R)-baclofen 69308-37-8
(R)-baclofen
分子式:C10H12ClNO2 分子量:213.66
产品描述
(R)-baclofen是一种γ-氨基丁酸衍生物,主要用于治疗痉挛。
靶点
IC50
体外研究
Baclofen is a skeletal muscle relaxant used in the treatment of spasticity of spinal and cerebral origin. Although it is marketed as a racemic mixture, only the baclofen R-enantiomer is stereospecifically active at so called GAGAB-receptors. Researchers believe that the enantiomers of baclofen have different properties. It is claimed that the R-(−)-enantiomer is about 100 times more active than the S-(+)-enantiomer.
体内研究
溶解性
DMSO <1 mg/mL,水 8 mg/mL,乙醇 <1 mg/mL
稳定性
2年 -20°C粉状,6月-80°C溶于DMSO