NDGA （Nordihydroguaiaretic acid） 500-38-9

NDGA (Nordihydroguaiaretic acid) 500-38-9

 NDGA (Nordihydroguaiaretic acid)
分子式：C18H22O4   分子量：302.36
 
产品描述
Nordihydroguaiaretic acid (NDGA)是一种天然苯酚化合物，由灌木Larrea divaricata的杂酚油中分离得到，在体外和体内都具有抗癌活性。它的类似物已经进行临床开发，用于治疗难治性的实体肿瘤
靶点
           
IC50
           
体外研究
NDGA may also direct target mTORC1 complex because NDGA suppressed amino acids- and insulin-stimulated mTORC1 and acted like rapamycin to disrupt mTOR-Raptor interaction. NDGA increased PPARα promoter activity in AML12 hepatocytes and also prevented the fatty acid suppression of PPARα expression. In contrast, PPARα siRNA abrogated the stimulatory effect of NDGA on fatty acidcatabolism
体内研究
NDGA was able to induce Nrf2 translocation in vivo in kidneys of rats submitted to both U-NX and I/R injury and to protect against renal histological damage and apoptosis . Comparison of the proportion of live mice at the age of 90% mortality was used as a surrogate for measurement of maximum lifespan;neither NDGA (p=0.12) nor aspirin (p=0.16) had a significant effect in this test. Measures of blood levels of NDGA or aspirin and its salicylicacid metabolite suggest that the observed lack of effects of NDGA or aspirin on life span in females could be related to gender differences in drug disposition or metabolism
溶解性
DMSO 微溶，乙醇 微溶，水 不溶
稳定性
2年 -20°C粉状，6月-80°C溶于DMSO