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Torin 21223001-51-1

更新时间:2024-05-25

访问量:459

厂商性质:经销商

生产地址:上海一基

简要描述:
Torin 21223001-51-1
上海一基实业有限公司是主要从事配套试剂的生产和销售的企业,产品用途:科研实验,标准对照品研究中心代理的作为一种衡量标准

Torin 21223001-51-1

Torin2
分子式:C24H15F3N4O  分子量:432.4
 
产品描述
Torin 2是有效的,选择性mTOR抑制剂,IC50为0.25 nM;作用于mTOR比作用于PI3K选择性高800倍,且增强药代动力学特性,抑制ATM/ATR/DNA-PK,EC50分别为28 nM/35 nM/118 nM。
靶点
mTOR
         
IC50
0.25 nM
         
体外研究
Torin 2 has the same binding mode as PI3Kγ, V882 serves as a hinge binding point and in the inner hydrophobic pocket Y867, D841 and D964 provide three more hydrogen bonds with aminopyridine side chain analogous to Y2225, D2195 and D2357 of mTOR.Torin 2 inhibits mTORC1, thus activates TFEB by promoting its nuclear translocation with EC50 of 1.666 mM.Torin 2(< 50 nM) causes a significant reduction in viability of both MZ-CRC-1 and TT cells. Torin 2 (100 nM) exerts a significant reduction of migration of both MZ-CRC-1 and TT cells.
体内研究
Torin 2 exhibits >95% pharmacodynamic response and half-time of 11.7 min in the mouse liver microsome stability study. Torin 2 exhibits the best bioavailability (51%), short half-life (0.72 hours) and low clearance(19.6 mL/min/kg) in male Swiss albino mice following intravenous and oral administration.Torin 2(20mg/kg) ablates MYCN tumors with reduction in MYCN protein levels and induction of apoptosis in Th-MYCN mice.
溶解性
DMSO 20 mg/mL,水 <1 mg/mL,乙醇 <1 mg/mL
稳定性
2年 -20°C粉状,6月-80°C溶于DMSO

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