产品中心您的位置:网站首页 > 产品中心 > 生物试剂 > 其他生化试剂 > 1391108-10-3BM-1074 1391108-10-3

BM-1074 1391108-10-3

更新时间:2024-05-23

访问量:272

厂商性质:经销商

生产地址:

简要描述:
BM-1074 1391108-10-3
上海一基实业有限公司是主要从事 标准品、配套试剂的生产和销售的企业,产品用途:科研实验,标准对照品研究中心代理的作为一种衡量标准。

BM-1074 1391108-10-3

 BM1074
分子式:C50H57ClN8O7S3分子量:1013.68
 
产品描述
BM-1074是有效的Bcl-2/Bcl-xL抑制剂,Ki为<1 nM,抑制Mcl-1活性。
靶点
Bcl-2/Bcl-xL
 
 
 
 
 
IC50
1 nM (Ki)
 
 
 
 
 
体外研究
BM-1074 inhibits FP-based binding affinities of Bcl-2/Bcl-xL with IC50 of 1.8 and 6.9 nM, respectively. BM-1074 inhibits growth of small-cell lung cancer cell lines H1963, H187 and H1417 with IC50 of 1, 1.4 and 2.3 nM.
体内研究
BM-1074, administrated at a single dose of 15 mg/kg, induces robust cleavage of PARP and caspase-3 at both 3 and 6 h time points in H146 xenograft tumor tissues. BM-1074 (15 mg/kg) is capable of achieving rapid, complete, and persistent tumor regression. 18 days after the treatment is ended, none of the mice treated with BM-1074 has measurable tumors, and 74 days after the end of the treatment with BM-1074, 50 % animals do not have measurable tumors. The average tumor size for the all mice are 47 mm3 at day 117, as compared to 130 mm3 at the start of the treatment. All the mice treated with compound BM-1074 suffers no significant weight loss (<5%) and do not show other signs of toxicity during or after the treatment. 
溶解性
可溶于DMSO
稳定性
2年 -20°C粉状,6月-80°C溶于DMSO
特征
 

留言框

  • 产品:

  • 您的单位:

  • 您的姓名:

  • 联系电话:

  • 常用邮箱:

  • 省份:

  • 详细地址:

  • 补充说明:

  • 验证码:

    请输入计算结果(填写阿拉伯数字),如:三加四=7