PD168393 194423-15-9
PD168393
分子式:C17H13BrN4O 分子量:369.22
产品描述
PD168393 是不可逆EGFR抑制剂,IC50为0.70 nM,不可逆烷基化Cys-773;抑制insulin, PDGFR, FGFR 和PKC活性。
靶点
IC50
体外研究
A potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM). Does not inhibit other protein kinases. Acts by binding to the catalytic domain of the EGFR with a 1:1 stoichiometry and alkylating Cys773
体内研究
溶解性
DMSO 74 mg/mL,水 <1 mg/mL,乙醇 <1 mg/mL
稳定性
2年 -20°C粉状,6月-80°C溶于DMSO