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Latrepirdine97657-92-6

更新时间:2024-07-19

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简要描述:
Latrepirdine97657-92-6
上海一基实业有限公司是主要从事配套试剂的生产和销售的企业,产品用途:科研实验,标准对照品研究中心代理的作为一种衡量标准。

Latrepirdine97657-92-6

Latrepirdine
分子式:C21H25N3.2HCl   分子量:392.37
 
产品描述
Dimebon是一种抗组织胺的药物。
靶点
 
 
 
     
IC50
 
 
 
     
生物活性
Latrepirdine (INN, also known as dimebolin and sold as Dimebon), is an antihistamine drug. Research is continuing in both Russia and western nations into potential applications as a neuroprotective drug to combat Alzheimer’s disease and, possibly, as a nootropic as well. However, a Phase III clinical trial for Alzheimer’s disease treatment failed to show any benefit.
Latrepirdine operates through multiple mechanisms of action, blocking the action of neurotoxic beta-amyloid proteins, inhibiting L-type calcium channels, modulating the action of AMPA and NMDA glutamate receptors, exerting a neuroprotective effect by blocking a novel target that involves mitochondrial pores, blocking a number of other receptors including α-adrenergic, 5-HT2C, 5-HT5A, and 5-HT6.
溶解性
DMSO 24 mg/mL,水 79 mg/mL,乙醇 13 mg/mL
稳定性
2年 -20°C粉状,6月-80°C溶于DMSO

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