产品中心您的位置:网站首页 > 产品中心 > 生物试剂 > 其他生化试剂 > 99291-25-5Levodropropizine99291-25-5

Levodropropizine99291-25-5

更新时间:2024-04-12

访问量:393

厂商性质:经销商

生产地址:

简要描述:
Levodropropizine99291-25-5
上海一基实业有限公司是主要从事配套试剂的生产和销售的企业,产品用途:科研实验,标准对照品研究中心代理的作为一种衡量标准。

Levodropropizine99291-25-5

Levodropropizine
分子式:C13H20N2O2   分子量:236.31
 
产品描述
Levodropropizine 可以抗过敏并抑制组胺受体, 通过干扰外围感觉神经末端的刺激激活以及调节参与咳嗽反射的神经肽来减轻咳嗽。
靶点
           
IC50
           
体外研究
Levodropropizine has affinity for H1-histaminic and alpha-adrenergic receptors without affinity for H1-histaminic and alpha-adrenergic receptors.
体内研究
Levodropropizine has weaker central sedative effects than the racemate and it does not induce physical dependence in rats. Levodropropizine (15 mg/kg, i.v.) reduces both the duration of apnoea and the response of the C-fibre to phenylbiguanide. The LVDP-induced inhibition of the C-fibre response to PBG is on average 50% in pulmonary and 25% in non-pulmonary fibres. Levodropropizine is shown to have good antitussive activity in anaesthetized guinea-pigs and rabbits. Levodropropizine (i.v.) is 1/10 to 1/20 as active as codeine and comparable to dropropizine on mechanically and electrically induced coughing in rabbits and guinea-pigs. Levodropropizine (orally) is comparable with those of both dropropizine and codeine against coughing induced by irritant aerosols. Levodropropizine (40 μg/50 μL i.c.v.) does not prevent electrically-induced cough, while Codeine (5 μg/50 μl i.c.v.) markedly prevents coughing in guinea-pigs. Levodropropizine has a peripheral site of action which is related to sensory neuropeptides. Levodropropizine (10 mg/kg, 50 mg/kg and 200 mg/kg) reduces in a dose-dependent manner the extravasation of Evans blue dye evoked by capsaicin in the rat trachea. Levodropropizine (200 mg/kg) inhibits also substance P-evoked extravasation, whereas it does not affect the extravasation evoked by plaet activating factor.
溶解性
DMSO 47 mg/mL,水 15 mg/mL,乙醇 47 mg/mL
稳定性
2年 -20°C粉状,6月-80°C溶于DMSO
特征
Levodropropizine have a better tolerability index than the Racemate.

留言框

  • 产品:

  • 您的单位:

  • 您的姓名:

  • 联系电话:

  • 常用邮箱:

  • 省份:

  • 详细地址:

  • 补充说明:

  • 验证码:

    请输入计算结果(填写阿拉伯数字),如:三加四=7