EPZ004777 1338466-77-5
EPZ-004777
分子式:C28H41N7O4 分子量:539.67
产品描述
EPZ004777是有效的,选择性DOT1L抑制剂,IC50为0.4 nM。
靶点
DOT1L
IC50
0.4 nM
生物活性
A potent and selective DOT1L inhibitor. Treatment of leukemic cells with EPZ004777 results in selective killing of those cells bearing the MLL (mixed lineage leukemia) gene translocation, with little effect on non-MLL-translocated cells.
溶解性
可溶于DMSO
稳定性
2年 -20°C粉状,6月-80°C溶于DMSO