VU 0364439 1246086-78-1
VU-0364439
分子式:C18H13Cl2N3O3S 分子量:422.29
产品描述
VU 0364439是mGlu4正性变构调节剂(PAM), EC50为19.8 nM。
靶点
mGluR4
IC50
19.8 nM
体外研究
体内研究
VU 0364439 possess less than ideal PK properties preventing their use as in vivo tools. It shows better stability in HLM (63% remaining) than RLM (2% remaining).
溶解性
DMSO 85 mg/mL,水 <1 mg/mL,乙醇 <1 mg/mL
稳定性
2年 -20°C粉状,6月-80°C溶于DMSO
特征
VU 0364439 is the most potent mGlu4 PAM reported to date.